Health Matters

Tyrosine also helped me with tooth nerve pain starting at 500mg in early morning on empty stomach, and no food near it.. but it does build up after a while and usually leads to crankiness. Worth it for pain relief, but its time to stop when you start getting too easily aggravated. For me, the intensity of pain was permanently reduced.. like the pain level rose gradually again on stopping but not to the same intensity level.
was looking back on old babble records, back nov 2003

"Recently, AADC, which catalyzes the formation of 5-HT, has been found in the smooth muscle cells of human dental pulp arterioles and elevated AADC activity has also been found throughout the human dental pulp [7]. Thus, the localization of AADC and MAO in blood vessel walls of human dental pulp suggests a functional relationship between AADC and MAO in the metabolism of 5-HT. The presence of 5-HT, AADC and MAO in the arteriole wall of human dental pulp may be important for neurohormonal regulation of blood flow and blood pressure under normal and pathological conditions. "

from link

http://en.wikipedia.org/wiki/L-DOPA

from tyrosine

http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase from tryptophan.. both need armomatic L-amino acid decarboxylase.. so could promote the production by increasing B6 intake.. or by taking tyrosine .. to stop the tooth pain.
I still get tooth pain taking B6 only? I could stop it with tyrosine,
BUT B1 rediuces it a lot, but doesnt completely stop it as tyrosine does. With me, tyrosine also seemed to alleviate the nerve pain even after stopping tyrosine. The intensity is lowered a lot.
THis may explain why B1 helps.. Thiamine deficiency:
It seems that b1 may improve serotonin uptake.. maybe mine is stuffed after years of SSRI's , but I haven't touched any for 6 years or more now.

The tryptohan may or may not work for tooth pain?? . I havent tried it, or noticed it. I can't recall having any pain while trialling tryptophan, but I have never taken it when experiencing nerve pain either... but maybe IF ssris's do work it does work.. I just havent personally heard of anyone for who SSRI's DO actually work as intended and stay working!! only partially!! SSRI's have an effect on depression(mostly in first few months only) of slightly, (about the same effect B1 has on lifting brain fog) alleviating depression for me, but also had many other effects
enzyme http://www.expasy.org/cgi-bin/nicezyme.pl?4.1.1.28 cofactor B6
I've never personally read or heard of anyone for who SSRI"s or tryptophan or 5HT has alleviated tooth/nerve pain at all. This doesn't fit!!
I'm not saying the below doesn't apply. I was just wondering if B1 was a cofactor at all.. but can't find it as any.

"The presence of 5-HT, AADC and MAO in the arteriole wall of human dental pulp may be important for neurohormonal regulation of blood flow and blood pressure under normal and pathological conditions."
" Recently, AADC, which catalyzes the formation of 5-HT, has been found in the smooth muscle cells of human dental pulp arterioles and elevated AADC activity has also been found throughout the human dental pulp [7]. "

http://www.genome.ad.jp/dbget-bin/show_pathway?map00350+4.1.1.28
KEGG tyrosine pathway
in red the enzyme AADC. It shows its needed to get from tyrosine to dopamine.. but not needed to go on to adrenaline, so that bit is out. However once the dopamine poathway, and its branches are saturated.. it does flow(way too much) to increased noradrenaline/adrenaline.. for some it does immediately, causing unreasonable aggression, crankiness (like throwing your pet dog out with the boyfriend).
Off track, I wonder if parkinson patients given l-dopa (I think?) have this flow thru to too much agression problem? It does seem to happen within weeks at the longest in everyone who has tried tyrosine that I have heard of. Days for others.
Still for me it was worth he decrease in pain , especially as the intensity of the pain was lowered after stopping.(it did come back gradually but not to the anywhere near same level)

However, AADC increased may increase the amount of dopamine produced in our body.. and reduce symptoms like tremours( not that I have them).
Should increase formation of tyramine too.. not sure if that is great or not? I'm sure we all need some though.

http://www.genome.ad.jp/dbget-bin/show_pathway?map00380+4.1.1.28
KEGG Tryptophan metabolism - Reference pathway

In red the anyzme AADC. Necessary for production of serontonin and tryptamine.

all pathways of enzyme
http://www.genome.ad.jp/dbget-bin/www_bget?ec:4.1.1.28

I guess with both increased enyzme utilization (via cofactor B6) and increased produced product (which is sure to feed back on the loop even if NOt specified as that's how most things work in the body!) one will get a stop or slowing after a while of production of dopamine etc.. unless it converts to something else..which is what happens with dopamine
with serotonin.. and melatonin..after a while they build up I guess and more enzyme or substrate (tryptohan or 5HT) will not do much, which Is how we would want it anyway.
Plus the incr serotonin would lower receptor levels etc.. which is what happens in practise as felt by all.

COPPER is neede for this bit
http://www.genome.ad.jp/dbget-bin/www_bget?enzyme+1.14.18.1
http://www.genome.ad.jp/dbget-bin/show_pathway?map00350+1.14.18.1

IRON is needed here
http://www.genome.ad.jp/dbget-bin/www_bget?enzyme+1.14.16.2

B6 is needed here
http://www.genome.ad.jp/dbget-bin/www_bget?enzyme+4.1.1.25
http://www.genome.ad.jp/dbget-bin/show_pathway?map00350+4.1.1.25
as well as B6 being needed for AADC 4.1.1.28 (both on same part of path)

According to TH, enzymes are almost always in excess.. but he never said nothing about the cofactors!

could also be related to this
http://www.the-aps.org/press/conference/eb03/11.htm
"Summary

The present studies demonstrate that spinal application as well as intraperitoneal injection of vitamin B1, B6, B12 their combination can produce short- and long-term inhibition of hyperalgesia following chronic compression of dorsal root ganglion neurons produced by artificial intervertebral foramen stenosis. Both severity and duration of hyperalgesia are significantly reduced. These results strongly support clinical use of B-vitamins in aiding in treatment of chronic pain and/or other diseases due to similar injuries to the nervous system.

The data also show that vitamin B1 induced-inhibition of hyperalgesia can be reversed by the inhibitors of cGMP-PKG signaling pathway, suggesting that vitamin B1 induced- inhibition of hyperalgesia due to spinal ganglion compression may involve, at least in part, in activation of the cGMP-PKG signaling pathway in the spinal cord. "

the above may be what the endo was referring to when i said that B1 , which I'd commenced, was alleviating the feet burning to some extent..and he said.. yes, it would. He had previously said he didnt think I would be deficient in B1 as it was rare, so not worth testing, so maybe he was referring to this.. if so, its a pity he didnt mention it!

[[....Thiamin deficiency can result from inadequate thiamin intake (for example in chronic alcoholics, patients receiving intravenous feeding/parenteral nutrition for more than 7 days without multivitamins or dietary thiamin, or those living in countries with principally carbohydrate-based diets); increased body requirements for thiamin (such as with strenuous exercise, malaria, HIV infection, hyperthyroidism , fever, severe liver disease, pregnancy, breastfeeding, or adolescent growth); excessive loss of thiamin from the body (for example in patients with kidney failure on dialysis or those taking diuretics); or consumption of large amounts of anti-thiamin factors in foods (such as coffee, tea, betel nuts, vitamin C, raw freshwater fish, shellfish, ferns, or African silkworms).Effects: Severe chronic thiamin deficiency can result in potentially serious complications involving the nervous system/brain, muscles, heart, and gastrointestinal system....]]

Elaine has also mentioned low B1 in hyperthyroid.

http://www.ithyroid.com/hypert_recovery_story.htm

" copper deficiency" leads to "foggy thinking, "brain fog""
"The foods high in copper are shellfish (oysters, clams, crab and lobster), organ meats like liver, dried fruits like raisins and dates, beans, beer made in copper vats, and chocolate"
"Chocolate craving seems to be a sure sign of copper deficiency "
"Wallach states that copper is essential for iodine utilization and is therefore critical for thyroid health.
>

"B-1 (200-500 mg a day). B-1 (thiamine) seems to be the critical B vitamin for copper utilization"
"B-2 (100-200 mg a day). Seems to assist copper and boron utilization and helps eye problems." I found an increased need for B2 when I took B1 injections. Before, even 5mg of B2 made bright yellow urine.. with the injections I got cracks in the corners of my mouth which could have been B2 or biotin deficieny ( I also took 1000mcg twice a day (2mg in toal) of biotin sublingiuals). I took B2 tablets (about 25 mg every day ). between this and biotin , the cracks went away.. but with this much b2 for a few days with the cracks my urine did not go a strong bright yellow (only weak, diluted).. so i must have been using it!

"B-6--This seems to be the major B vitamin which increases utilization of zinc"
I found this out about 20 years ago. I was short on zinc and always supplementing on and off.. but I needed to take B6 and some Mg as well for better absorption. Once I started thyroid meds, my need for zinc disappeared..so it is used it making thyroid hormones.
"Zinc--This seems to be the major stimulator of the thyroid ".. I agree with this

"Yoghurt supplies vitamin K" I didn't know that? ; must check on

Hyalunoric acid..for less wrinkles, great hair, and hot flushes instead of oestrogen in menopause??????

I cant ship this to Oz.. Amazon doesnt ship to Oz and I had trouble with quarantine last time
http://www.shopping.com/xPC-Hyaluronic_Acid_Complex_60_Capsules#
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I went to the chemists(Soul pattinsons at Miranda) and he looked up hyaluronic acid for me. He could source it(at a cost to him) of $1000/g (thousand/gram..not a typo ..so I'm looking for a cheaper source.
I got some chicken carcasses from the local chicken shop yesterday at $1.50 per kg. I found out the sternum is where the wings attach, and its a cartilage (more transparent colour).
After boiling chickens for about20 minutes, I could easily just peel off the sternum, if I started at the right end!
I'm not sure about uncooked??? I wouldn't eat them uncooked though due to bacteria/germs/viruses..especially after I get the carcasses from a chicken shop!..way too unhealthy. Not sure what the minimum I could safely boil for is.. probably 20 mins??

I found all bits and pieces inside the carcass too.. looks like testes??. hmmm. Have to find out what! I found a piece of the liver(rest cut out), and kidneys too.
Its just these testes and adrenals I'm interested in(hormonal stew anyone??), if the hormones are lost with boiling either!.
These testes are in the shape of a cresent moon and very pale yellow/white in colour.. (there inside in a rooster). Yes they were testes(I found out in a book, and they can be a lot larger and bean shape.
Apparently the testes can be quite big in a rooster when hormonal.. or whatever its called
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I tried making some chicken stock a few days ago.. to get the sternums. After boiling 4 chickens for 5 hrs I couldnt find the sternums.. so either the dogs got that in the chicken meat/bones bit, or I did in the stock! I had a bit of a munch on all bones anyway.. just in case, and I figured the calcium would be good anyway. Boiled chicken tastes yuk.. even with garlic, bay leaves, pepper, kelp(as a salt replacement) etc added!
Got some good stock made though.

So next 4 chickens I just boiled for 20 mins or so and took out and peeled off the sternums..dogs are enjoying the rest!

It's not something one does in Qld.. too hot for soups etc , so It's new to me.
---------------

The new dietary ingredient is Colloral brand Type II Collagen, which is prepared from
chicken sternal cartilage. Type II Collagen is the predominant form of collagen in the
sternal cartilage and accounts for 40% to 45% of the dry weight of the cartilage. Type II
Collagen molecules are trimers of a single type of collagen chain. Each chain contains a
large domain that participates with two others to form a triple helix. At both ends of the
triple helical domain are telopeptides that have a less defined tertiary structure. In
cartilage, the trimers associate in a staggered array to form fib&. The fibrils are
stabilized by enzymatically formed aldehyde-derived cross-links between the triple
helices. Enzymatic digestion cleaves these cross-links releasing single triple helices of
Type II Collagen.
To obtain the new dietary ingredient, Colloral Type II Collagen is separated from other
components of sternal cartilage. The chicken sternum is surrounded by a perichondrium
composed predominantly of Type I collagen, which is removed with the enzyme pepsin
during an initial preparation step. Proteoglycan, which comprises about 50% dry weight
of the sternal cartilage, is removed from the sternal cartilage by preliminary digestion
with trypsin. The sternal cartilage also contains small amounts of other types of collagen
(Types V, VI, IX and XI) that differ from Type II in their amino acid sequences. These
collagens are removed by differential salt precipitation.
http://www.fda.gov/ohrms/DOCKETS/dockets/95s0316/rpt0088_01.pdf

So I figure.. just eat chicken sternums.. now does it matter if they are boiled or not? I mean, is the haluronic acid lost or altered by boiling?

-----------------------
point to note.. high iron is BAD.. it ages and wrinkles you fast.. which is probably why I looked so young for my age for decades until I tried to get my ferritin up.. I also noticed a huge incr in anxiety and tension with the higher iron level (about 37 I got to).. anywhere in high 20's is fine for me I now think!(under 25 I'll try to supp slowly only!I KNOW 10 and 15 feel bad!)
I felt really bad there for a while, overdid the iron and my iron levels went high(above normal range).. but ferritin never went over the 37 mark.. so I figure 25 or above is OK for me.

also iron + vitC is really BAD!! .. which I was doing to absorb the iron!! huge sigh
also in below link it says " Vitamin C in combination with iron helps to break down HA "

http://www.drpasswater.com/nutrition_library/Sardi.html (copyrighted)
© Whole Foods Magazine
my link (private)

http://www.cheque.uq.edu.au/research/bioengineering/research/Metabolic_Engineering/HA.html

http://www.vrp.com/art/1210.asp

http://www.westonaprice.org/foodfeatures/brothisbeautiful.html

I tried gelatine out at beginning of the year...and made myself low in tyrptophan.!! (its missing from gelatine).
The first lot of gelatine felt good, then I felt low on melatonin and serontonin.. so I ended up buying some tryptophan to help me over the shortage..it seemed to work too.(I did try high tryptophan foods like turkey, chicken and milk etc.. but it was not "pulling me out enough".. or it would have taken many months!)
Lesson: don't eat an unbalanced diet!!
It appears that gelatine in modern times is made from skins only.. not how it used to be made with bones and all sorts of things.. so its a unbalanced ..fine to include in a balance with other foods though.
Chicken stock(broth) avoids this..it has everything in it.. and it feels a lot better than just the just gelatine.. it could be the tryptophan, or hormones as well as the other stuff in it. I've learnt my body likes a balance, but there's nothing wrong with a bit of gelatine!.. .
(As an aside, that link made a point about glycine(a compnent of gelatine) helping one's body cope with benzoic acid.. which is a preservative used in foods and drinks)

chicken sternum collagen are sources used to produce oral HA supplements .. OK, I found if I boil them for about 20 mins, I can easily peel them from the chicken carcass and then munch on them when cold..not exactly tasty.. but not dreadful either!

I'm hoping I'll be able to walk without pain again at least.. always hopeful here. I'm also taking glucosamine, chondroitin sulfate, MSM powder mix..but I took this before over a year ago with litle effect.. maybe I shouldnt have stopped it though! I'm hoping this TOGETHER with the lightly boiled and peeled off chicken sternums, and some more stock will work! I'm hoping it stops hot flushes and help with knees too that are playing up on me!
If anyone else tries this for hot flushes or painful/weak/giving way joints and it works for them.. let me know! Thanks!
and I'm not even 100 yet!!! huge sigh

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update on Saturday 12th August
I'm not sure how much hormones I got out of that chicken stock I made.. but it could have some adrenals, testosterone, .. maybe thyroid.. must check around the chickens neck??
Last night I slept thru and no sweats.. first time. I ate a pile of stock mixed in with a tin of vege soup, and 3 chicken sternums to munch on.. now I have to make some more...
I have been sleeping a long time at night too for past 3 days(about 11 hrs), and now back to a normal 9 hrs...and SLEPT right thru!!.. that's first time ever for that.
I really have no idea if I'm getting any hormones or not here. Larrian talked of the arginine in chcicken stock ... maybe its that instead?
-------------------------------

Glycine ( a component of gelatine in the chicken stock) may help increase growth hormone, probably only in those low in growth hormone and not as fit as professional footballers etc!(who have already optimized their natural growth hormone thru training if not by added creatine and other supps)
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Here's something different.
I've heard of VitD in the parathyroid hormone-calcium-phosphate-vitD3 loop, Also also of vitD needed to prevent fatigue and depression..but I hadn't heard of VitD and testes before.

I was making chicken stock from chicken carcasses and found inside the chicken carcass some testicles. I was looking to check, when I came up across this article

Summary

Studies have examined the effects of vitamin D-deficiency on various tissues of different species, especially on reproductive functions of male and female chickens. The present study is an attempt to unveil the effects of vitamin D-depletion on the morphology of chicken testes. White leghorn male chicks were raised from 1 day to 12 weeks of age in vitamin D-repleted and -depleted groups. Chickens were weighed before they were euthanized, and testes were weighed after removal. Morphology of the testes from the groups was examined histologically using H&E-stained sectiones. The results revealed a significant difference in the morphology of the seminiferous tubules between the groups. Marked alterations in the appearence of the seminiferous tubules of the vitamin D-depleted chickens were characterized by immature seminiferous tubules that were smaller in diameter and poorly organized as compared to the normal morphology in the vitamin D-repleted group. Disruption of the spermatogenesis in the seminiferous tubules of vitamin D-depleted chickens indicated the necessity of vitamin D in testis development

"testicular weight of vitamin D-depleted group (mean 1.95 gm) was also significantly lower than that of vitamin D-repleted group (mean 5.44 gm)"

"The testes of vitamin D-depleted animals showed incomplete spermatogenesis, impaired development, and degenerative changes in the seminiferous tubules"

BUT it seems better to just replace at the normal optimal level.. not as a large initial "hit", as is done by injection of docs in humans sometimes?

"The reduction in fertility of vitamin D-deficient female and male rats is reversible and can be restored by simply supplementing an optimal dose of vitamin D...
However, a high dose of vitamin D administration, in this study, deteriorated the testicular function in vitamin D-deficient male rats"
more
EFFECTS OF VITAMIN-D DEPLETION ON CHICKEN TESTES
Israel Veterinary Medical Association Vol. 57 (2) 2002

OK, It's no chickens and rats.. but

Studies have demonstrated that the "mild-to-moderate iodine deficiency for the health of the population is associated with a high occurrence of hyperthyroidism in elderly subjects, especially women, with risk of cardiac arrhythmias, osteoporosis, and muscle wasting."

 "The hyperthyroidism is caused by autonomous nodular growth and function of the thyroid gland and it is accompanied by a high frequency of goiter. "

full abstracts and refs are here
http://tealady.blog.co.uk/2006/08/08/iodine_deficiency_and_hyperthyroidism~1022248
http://tealady.blog.co.uk/2006/08/08/iodine_deficiency_was_associated_with_a_~1022256

"Results: The study showed profound effects of even small differences in iodine intake level on the prevalence of goiter, nodules, and thyroid dysfunction.
Mild and moderate iodine deficiency was associated with a decrease in serum TSH with age"

"There were more cases of overt hypothyroidism in mild than in moderate iodine deficiency caused by a 53% higher incidence of spontaneous (presumably autoimmune) hypothyroidism.
On the other hand, there were 49% more cases of overt hyperthyroidism in the area with moderate iodine deficiency.
The cautious iodine fortification program, aiming at an average increase in iodine intake of 50 µg/day has been associated with a 50% increase in incidence of hyperthyroidism in the area with the most severe iodine deficiency" 

So its important to get some iodine, but not too much.
Also a sudden incr to what may be considered "optimal" levels can be dangerous.

Also see Iodine for lowish thyroid hormone (slightly raised TSH)

Salt as a carrier of iodine in iodine deficient areas.
Burgi H, Zimmermann MB.

Fluorine-Iodine Commission, Swiss Academy of Medical Sciences. buergi@smile.ch

In the past 80 years, salt has proved a reliable, safe, cheap and stable carrier to correct iodine deficiency on a large scale. Salt is available and consumed everywhere in the world. The per capita daily consumption (a decisive figure for calculating the iodine dosage) is roughly the same under the most varied cultural conditions, namely 8 to 12 grams. An overdose of salt (and thereby of iodine) is virtually excluded. The iodine content of salt is reasonably stable, provided KIO3 (instead of KI) and low-density polyethylene bags for packaging are used under adverse climatic conditions.

my last iherb order(taken over by Papa something).. they didnt include a list of ingredients attached on outside(iherb used to!.. but thry don't and didnt' reply to my emails requesting this either!).. so it went to quarantine. I got it immediately..BUT I got charged a quarantine processing fee of almost $50!! .. just for opening to see it was Vitamin tablets etc.!!
They said its caus iherb put "nutritional supplements" on the outside of the parcel!
This is a red flag to Australian quarantine apparently(they told me).. it means funny herbs etc in their lingo.

http://www.daff.gov.au/aqis/mail/cant-mail
http://www.daff.gov.au/aqis/mail sending international Mail to Australia

http://www.butyoudontlooksick.com/2006/02/the_spoon_theory.php