On the ten news tonight they mentioned a study showed glucosamine producing a diabetic state 'within' cells, and also mentioned this may led to diabetes, and also infertility on some animals in the study. At least this was the gist I thought I heard?
I looked up the channel 10 news site.. but nix. BBC where are u!!
just posting this as a reminder to myself to find out more about this as I take a glucosamine chrondritin MSM powder mix to help with my knee joints, although I'm unsure if it has any effect, BUT I have been getting this 'intense burning'(more at some times than others, but always something PN-like, which seems to match the description of diabetic neuropathy in my feet.. so I'm wondering if glucosamine is causing or worsening this?
Searching on pubmed I found these below: but there is more. I did a pubmed search on "glucosamine diabetic within cells".
Glucosamine-induced insulin resistance in L6 muscle cells
Glucosamine induces lipid accumulation and adipogenic change in C2C12 myoblasts.
Biochem Biophys Res Commun. 2005 Mar 11;328(2):369-74.
PMID: 15694357 [PubMed - indexed for MEDLINE]
Hyaluronic acid production and CD44 expression in cultured dermal fibroblasts of patients with non-insulin-dependent diabetes mellitus with and without chronic ulcers on the lower extremity."We observed that diabetic fibroblasts of both groups produced more L-lactate ( approximately 30%) and incorporated more (3)H-glucosamine into the medium hyaluronic acid ( approximately 28%) than controls"
I got lost with this study, but it shows something is going on with hyaluronic acid and lactate
"Hyaluronic acid metabolism and CD44 expression are regulated by lactate, where their increased production is considered to affect the properties of fibroblasts in non-insulin-dependent diabetes mellitus"
Will look at more later...