I locate all the B1 posts by a tag search on B1.(just click on B1 under tags down RHS).
This is the "index" B1 post..and is still "under construction". , but hopefully may be helpful.
Also the whole blog can be searched by a google based search function in a search box way down RHS beneath the tags .
I did Food Chemistry at uni last semester, and a few things clicked ; like the sulfites destroying B1 and the effect of Ergot(it also acts to increase thyroid hormones and adrenal hormones;Ergotamin was the ONLY drug that relieved my migraines for years), and effect of thyroid hormones on B1 (see below).
I am wondering if I was near borderline low B1 usually and sulfites etc. or thyroid hormones just kick me below the edge, producing deficiency symptoms. My endo says no, as its rare; but I listen, then think about it.. ever hopeful
I think low B1 (perhaps the autoimmune absorption problem similar to pernicious anemia and B12 deficiency), or perhaps just from a combo of drinking tea and coffee and modern food processing and pehaps an occasional glass of wine. ..may be responsible for a lot of my symptoms and those of many others I know. Many other things can lower B1 too; like taking thyroid hormone meds or stress. I'm hoping to explain in more detail when I finish writing it up!!
I'm hoping to rewrite, if it turns out to be helpful under different heading.. like
B1 ..history
B1 symptoms of deficiency.. from major to mild (sub optimal) and maybe too much too much link2
The nervous and digestive systems are commonly the first to be felt by a slight deficiency of thiamin[e] (B1). Early syptoms incluse irritability, anxiety, depression, poor muscle tone, and not absorbing nutrients well (thiamin helps with the production of HCl in stomach). Poor muscle tone also results in constipation.
The amount of thiamin rrequired bears a close relationship with the amount of carbs consumed. Sugars and alcohol don't provide any thiamin and yet use it up in their metabolism. Thiamin in tthe 1990's has been added to white flour in Australia, but is still not added in NZ.
The US/Canada also adds B1 to white rice. In Australia this is not done, so depletion of thiamin can occur if too much white rice is eaten. This does happes in Asia, with severe depletion causing beriberi and deaths.
The white rice does contian thiamin .. but more gets used in the metabolism of the white rice.
I suspect the amount of thiamin consumed in metabolism of a food is closely correlated to its glycemic index.
B1 food sources
Natural Sources link1
Thiamine is present in lean pork/ham and other meats, wheat germ, liver and other organ meats, poultry, egg yolks, fish, beans and peas, nuts, and whole grains, brown rice,.
vegemite/marmite(if not destroyed in cooking?)
brewer's yeast (but beer will reduce B1 overall)
Dairy products, fruit and vegetables are not good sources.
The RDA is 0.5 mg per 1000 kcal, adequate for a healthy individual consuming a healthy diet.
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B1 loses .. some causes.. heat, cold, refrigeration, freeze drying, freezing, food processing, B1 added back to food.. flour/bread in 1991 in OZ ,, not yet added in NZ; added to flour,rice and something else too in US!! (as thiamine mononitrate in bread in Oz)
Considerable losses occur during cooking or other heat-processing of food.
Thiaminases-- inactivate thiamine link1(Australian), link2 (fish)
Polyphenolic compounds in coffee and tea can inactivate thiamine so that heavy use of these beverages could compromise thiamine nutrition (ref6).
b1 and sulfites link1 link2
B1 and apple cider
B1 and other foods with sulfites, SO2 etc ..and loses with sausages, and all foods incl sulfites,
also azo dyes in foods , tartrazine,
sulfa drugs
sulfates even?
B1 and alcohol link1, link2( to post 20 as a hypothesis only, refers posts 1 , 18 in thyroid forum thread)
B1 and caffeine, tea, coffee link1
Am J Clin Nutr. 1977 Oct;30(10):1680-5. says tannin is responsible for taking out vit B1 .. think milk binds tannins in tea? My symptoms seemed to worsen about when I started drinkng cranberry juice(which is high in tannnins), I already drank a lot of tea and some coffee occcasionally. Lately I got this taste on the back of my tongue and in my cheeks especially, but all over my mouth which I have now learnt to recognise as tannin(I think?). I guess it's like everything ..
The polyphenols /catechins/tannins or whatever you want to call them are great as antioxidants up to a certain point.... after which they become too high.. the lingering astringent taste in you mouth may let ya know (if its like me). Then too high tannins may reduce your B1?
I had developed a wosening of the PN in my feet and the burning sensation had become quite intense and was spreading up to my kness..that and an ever present fatigue and a on-off short term memory -concentration-thought problems whch seemed to be declining.I'm hoping that stopping drinking the cranberry juice, and trying to sip some milk may help with the "too high tannins" and my symptoms may lessen? I'm also taking some B1 and a high B1 diet though as well.
B1 and nitrates? strong suspicion due to own experiences with high levels of nitrates and nitrites(not so high levels needed of nitrites as nitrates) that nitrates reduce thiamine too... so careful here
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B1 autoimmune disease ..There's a rare autoimmune absorption problem similar to pernicious anemia and B12 deficiency. My endo says its rare even though tested for.. and yet I haven't been tested for it. I guess one would expect me to be skinny if I had this? .. just like I should be fat to have an autoimmune hypothyroid problem(which is why it took 15 yrs b4 anyone would test me for hypothyroid problems.. I didn't look it?)
.. now if I had , would I be in the middle??.. maybe not after thyrid hormone replacement..
still it's not something the medical profession seems to know a lot about, so I feel the benefit of the doubt should be applied here.
B1 and gastric acid
Taking B1 injections of thiamine hydrochloride has definitely made my gastric acid greatly increased.. lots of rumblings down there!
Also I feel salty and had to reduce salt intake.. still fele salty after taking for a month!
It could be the hydrochloride part .. or it could be the B1 itself?
I also take B1 sublinguals which are thiamine cocarboxylase.. and this also seems to increase my stomach acid.. and no HCl taken there..I think?? still thinking about this. the HCl form is definitely way too much to take 100mg a day in a tablet for me.. but again, it could be the HCL form.
I think I read somewhere about B1 increasing gastric(stomach) acid though.. must google on.
Effect of thiamine deficiency in hydrochloric acid secretion in the stomach Ok, a frog
maybe its just the HCl form in the tablets and the injections?
B1 .. phosphorylation problem
subheading under phosphorylation problem .. B1 and VitD
B1 and carbs and glucose levels in blood and diabetes(1 and 2)diabetes link1 and insulin resistance..
including giving B1 before glucose to hypoglycemia in diabetics etc, also includes B1 and epileptics carb_link1
The preference for low carb diets with many people could be suboptimal B1. Diets higher in carbs use up more B1. If one doesn't have sufficient B , fatigue(and others symptoms of a slight b1 insufficency) may result from a high carb diet as well as other symptoms: a general "don't feel as good" as on a low carb diet.
The B1 "sub optimal" , ie "marginal deficiency" may be caused by what is referred to as "high calorie malnutrition ". It's caused our modern lifestyle having too much food on hand..especially in the form of carbs (and this was promoted by the food pyramid!!). The problem does not occur(at least to same extent) if partially starving.. or don't get enough to eat to satisfy.. but do occur when have ample to eat!..as in US, K, Australia etc.
In other words, when we eat carbs to fill up (as they are cheap and convenient, and promoted!) we are using up our B1.. and with the modern day food processing, we are NOT replacing the B1.. hence we get fatigue and other symptoms of marginal B1 deficiency.
"Because thiamine is a major factor in the metabolism of glucose, it has long been known that ingestion of simple carbohydrates, processed in the body mainly to glucose, automatically increases the need for dietary thiamine. Thus, high calorie malnutrition is commonly associated with relative thiamine deficiency, irrespective of its fortification in food substances??" from http://ecam.oxfordjournals.org/cgi/content/full/3/1/49
B1 and diuresis, chloride channels (two posts from tag search on chloride).
B1 and heart
B1 and PN (peripheral neuropathy)
So what is PN? link1
exercise helps with PN.. probably by better circulation?, maybe reduced glucose.. B1 may be involved??.. an idea did flicker thru mind somewhere and now lost again
.. but I think (for me and a few others I have chatted to on forums) that similar happens with lower doses of thyroid hormones in a few of us that may be B1 deficient ..even on good diets?
Polyneuropathy from thiamin deficiency associated with thyrotoxicosis
B1 and MS link1(includes Klenner protocol of B1 and liver extract)
link2
B1 and thyroid link1
B1 and CFS/M.E.
www.geocities.com/bron.evans/cfs/cfs.html
B1 and dopamine [link] : in relation to CFS
B1 and Sjrogens link
B1 and Metabolic acidosis link1 link2
B1 and low adrenals link1
B1 and myofascial and tooth pulp pain
Bob finds garlic fixes some of this.(the link being garlic contains allithiamin.. another form of B1).
I noticed a difference with higher B1 too I think.(in injections link at present)
possibly via a serotonin uptake incr; link1
(Thiamine deficiency: selective impairment of the cerebellar serotonergic system).
I think that it's worth a trial of B1 or chewing garlic(if you can do it.. Bob advises NOT to try this on an empty stomach 
to see if it alleviates nerve pain, tooth pain, myofascial pain.
B1 and Candida link1
B1 and mercury link1
B1 and Ca, Mg Ca Mg link1, piracetam mentioned too
B1 and Glutathione, NAD(P)H link1
B1 and Oestrogen link1
I know there is something going on with estrogen and B1.
Other possible B1 deficiency diseases.. some suggestions..
maybe marginal B1 deficiency is behind SIDS in part ?
maybe Kawasaki disease,
others I've now forgotten again.. hey that's one.. memory, CFS etc.. may be involved to varying degrees migraines .. thru chloride permeability change? also may moderate low or high blood pressure also thru chloride channel permeability change..and perhaps a slight change in vasopressin??(hopeful here)
other end of scale...B1 and the athlete.. faster recovery time..due to faster lactate recycling between races .. may give an edge where a no of races in same day (maybe include, maybe not.. unsure if B1 makes it easier or harder to breathe duruing exercise..I seem to puff more.. but that could be nything, incl. I havent kept on my exercise schedule lately).. need to think on this..
Thiamin Metabolism link1
Thiamin .. technical High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms1
www.ajcn.org/cgi/content/full/75/4/616#SEC3
B1 supplement
FORMS OF B1 AVAILABLE IN SUPPS, why they work or dont work..and injections..and which studies SHOW THIAMINE WORKED and didnt work and which they used(may explain why some studie worked and some didnt.. the inconsistency of studies may be explained?).. also the combos of thiamine with other things like carbonates, citrates, nitrates, sulfates, sulfites.. esp in a multi.. storage of supps, fillers etc
Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats (NB nitrate form of water soluble thiamin nitrtae used cf benfotiamine(oil soluble and therefore effect longer lasting)
"Unlike treatment with water-soluble thiamine nitrate timely administration of liposoluble prodrug benfotiamine was effective in the prevention of functional damage"
Comparative bioavailability of various thiamine derivatives after oral administration
"After ingestion of a single dose of either 100 mg benfotiamin CS-benzoylthiamine-o-monophosphate), fursultiamin (thiamintetrahydrofurfuryldisulfide) or thiaminedisulfide, thiamine blood levels were analyzed for a 10-hour period"
oral administration of benfotiamin was best
Benfotiamine has been approved for use as a therapy for neuropathy in Germany for more than a decade. Furthermore, Benfotiamine is not just an pain killer, but actually improves nerve functioning. Free online abstracts of Benfotiamine studies include "Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy", "Therapeutic efficacy of 'Milgamma' in patients with painful diabetic neuropathy," and "A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy."
injections link1
injections link2
Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. Half-life of different thiamine species.
Other Recommended links
Excellent reviews and articles reading that are too broad to put in only one category
http://tealady-health.blog.co.uk/2006/06/27/b1_earlier_links_sent_to_gmail~901507
http://www.digitalnaturopath.com/treat/T157953.html
http://www.carleton.ca/biology/2200/slides/lecture12_06.pdf basic vitamin slides
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-thiamin.html
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/thi_0261.shtml