Alpa lipoic acid ( + Low dose naltroxene for autoimmune disease help including hashimoto thyroiditis perhaps)
http://articles.mercola.com/sites/articles/archive/2009/05/16/This-Antioxidant-Can-Smash-Insulin-Resistance-and-Autoimmune-Disease.aspx
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Low dose naltroxene + Alpha lipoic acid
@ Saturday, 16. May, 2009 – 09:11:15 pm
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Milk Thistle, Silymarin may help joints, arthritis
@ Tuesday, 05. May, 2009 – 09:14:30 pm
Milk thistle is one of my favourite feel-good supps I have used over many years. My knees are gimproving although I still have a twinge in my left knee, right kneee now fine.. I haven't taken consistently but maybe I should give it a try
Liver-Supporting Botanical May Also Improve Joint Health
by VRP.com
In a recently published clinical trial, researchers evaluated a popular botanical known for its role in liver health to determine if it also has anti-inflammatory activity in subjects with osteoarthritis of the knee.
In this study, silymarin, a constituent of milk thistle (Silybum marianum) long used to support liver health, was compared to 2 non-steroidal anti-inflammatory drugs (NSAIDS), piroxicam and meloxicam, in 220 patients with painful knee osteoarthritis (OA). Study subjects received one of 5 possible treatments: 300 mg per day of silymarin, 20 mg per day of piroxicam, 15 mg per day of meloxicam, or a combination of silymarin with piroxicam or meloxicam.
At the beginning of the study and after 8 weeks of treatment, subjects were evaluated for serum levels of cytokines interleukin-1 alpha, interleukin-8, and the complement proteins C3 and C4. Interleukin-1 alpha and interleukin-8 are cell signaling molecules and pro-inflammatory mediators. Complement proteins C3 and C4 are immune system proteins believed to play a role in some diseases such as arthritis.
The results showed that supplementation with silymarin significantly reduced serum levels of pro-inflammatory interleukin-1 alpha, interleukin-8, C3, and C4 after 8 weeks compared to the levels at the beginning of the study. Piroxicam reduced interleukin-8, but did not reduce interleukin-1 alpha. Meloxicam significantly elevated serum levels of interleukin-1 alpha but did not affect interleukin-8. Additionally, the NSAIDs showed a slight increase in serum levels of complement proteins after 8 weeks. However, combining silymarin with piroxicam, but not meloxicam, significantly reduced the cytokines interleukin-1 alpha and interleukin-8 and serum levels of complement proteins C3 and C4.
The researchers concluded, "Silymarin reduces the elevated levels of interleukins and complement proteins, when used alone, or in combination with NSAIDs for the treatment of knee OA."
Reference:
Hussain SA, Jassim NA, Numan IT, Al-Khalifa II, Abdullah TA. Anti-inflammatory activity of silymarin in patients with knee osteoarthritis. A comparative study with piroxicam and meloxicam. Saudi Med J. 2009 Jan;30(1):98-103.
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